VTD superieur aan VD als inductiebehandeling voor nieuwe myeloom patiënten die een autologe stamceltransplantatie kunnen ondergaan.

 De inductietherapie voor nieuwe multipel myeloom patiënten die een autologe stamcel transplantatie kunnen ondergaan is de laatste jaren sterk veranderd. Waar de voorbije 10 jaar de standaardbehandeling VAD (Vincristine-Adriamycine-Dexamethasone) was en later nog TD (Thalidomide-Dexamethasone) vinden de laatste jaren de novel agents een plaats in de kliniek. Tot recent bleek in de literatuur Velcade® -Dexamethasone (VD) een belangrijke verbetering op de oude schema’s. Echter, Cavo en collega’s (Italiaanse Myeloma Groep) tonen nu aan dat het toevoegen van thalidomide aan dit regime (VTD) de post-transplant outcome van de patiënten significant verbetert. Bovendien zouden voornamelijk de hoog risico myeloom patiënten (e.g. de patiënten met translocatie (4;14) ) een duidelijk voordeel halen uit de combinatie van een proteasoom inhibitor (Velcade® ) en een immunomodulatoir geneesmiddel (Thalidomide).
Auteurs : Dr. Karel Fostier & Dr. Ann De Becker

Baskiri Alzirska literatura . Cabeza de vaca . Desilikace vody Bayerischer wald . .

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